Exocrine Pancreatic Insufficiency (EPI) Therapeutics Market Provides An In-Depth Insight Of Sales And Trends Forecast To 2026

Press Release

Exocrine pancreatic insufficiency (EPI) is a condition associated with deficiency of exocrine pancreatic enzymes that results in the inability to digest food or maldigestion. EPI may be associated with certain diseases and conditions that affect the pancreas such as cystic fibrosis, chronic pancreatitis, Shwachman–Diamond syndrome, and others. Chronic pancreatitis (CP) is the most common cause of EPI in adults that is followed by cystic fibrosis (CF). CF is an inherited genetic condition that leads to chronic disease, which affects lungs, digestive, and reproductive system. Patients suffering from exocrine pancreatic insufficiency cannot properly digest proteins, fats, and carbohydrates in the food that results in poor absorption of nutrients in the body.

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Furthermore, EPI is associated with uncomfortable gastrointestinal (GI) symptoms such as bloating, gas, and oily diarrhea that floats and is difficult to flush. The symptoms of EPI may be similar to other gastrointestinal disorders such as Crohn’s disease, celiac disease, irritable bowel syndrome (IBS), ulcerative colitis, and small intestinal bacterial overgrowth (SIBO), which makes EPI  difficult to diagnose. However, there are three major tests used for diagnosis of EPI that include, fecal elastase test, fecal fat test, and direct pancreatic function test.

Exocrine Pancreatic Insufficiency (EPI) Therapeutics Market – Drivers

Exocrine pancreatic insufficiency is associated with certain diseases and conditions such as chronic pancreatitis, cystic fibrosis, pancreatectomy, pancreatic cancer, gastrointestinal surgery, type I and type III C diabetes, and other conditions including autoimmune pancreatitis, celiac disease, and inflammatory bowel disease. Moreover, high prevalence of these conditions leads to EPI, which in turn fuels growth of exocrine pancreatic insufficiency (EPI) therapeutics market. For instance, according to a report by the Cystic Fibrosis Foundation, 2010, around 1,000 new cases of cystic fibrosis are diagnosed globally every year.

Furthermore, according to a report by the American Lung Association, 2010, cystic fibrosis is the second most inherited disorder in infants in the U.S. The report further stated that around 10 million cases in the U.S are symptomless carriers of the defective cystic fibrosis gene and around 3,708 deaths were reported due to cystic fibrosis between 1999 and 2006. Moreover, pancreatic cancer is a major factor that leads to EPI.  According to Cancer Research UK 2015, around 9,800 new pancreatic cancer cases were registered in the U.K. annually, from 2013 to 2015. The report further stated that pancreatic cancer is the 11th most common cancer in the U.K. that accounted for 3% of all new cancer cases, in 2015.

Exocrine Pancreatic Insufficiency (EPI) Therapeutics Market – Competitive Analysis

Key players operating in the exocrine pancreatic insufficiency (EPI) therapeutics market include, AbbVie, Inc., Digestive Care, Inc., Janssen Pharmaceuticals, Inc., Anthera Pharmaceuticals, Inc., Allergan plc, AzurRx BioPharma, Inc., and others. Key players operating in this market are focused on product regulatory approvals and acquisition strategies to enhance their share in the market. For instance, in May 2013, AbbVie, Inc. announced the availability of CREON (pancrelipase) 36,000 Lipase-unit Capsules for patients with EPI in the U.S. Furthermore, in May 2018, VIVUS, Inc. entered into definitive agreement with Janssen Pharmaceuticals, Inc. to acquire all the product rights for PANCREAZE (pancrelipase) delayed-release capsules in the U.S. and Canada.

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Exocrine Pancreatic Insufficiency (EPI) Therapeutics Market – Taxonomy

By Disease Management

  • Nutritional Management
  • Pancreatic Enzyme Replacement Therapy (PERT)

By Therapeutic Drugs

  • Creon
  • Zenpep
  • Pancreaze
  • Ultresa
  • Viokace
  • Others

Exocrine Pancreatic Insufficiency (EPI) Therapeutics Market – Regional Analysis

Geographically, the global Exocrine Pancreatic Insufficiency (EPI) Therapeutics Market is segmented into North America, Latin America, Europe, Middle East, Asia Pacific, and Africa. North America is expected to dominate the global exocrine pancreatic insufficiency (EPI) therapeutics market due to increasing incidence and prevalence cases of these conditions occurring in this region. EPI is mostly characterized with its associated conditions such as cystic fibrosis, pancreatic cancer, chronic pancreatitis, gastrointestinal surgery, and others.