Saline Laxatives Market by types, applications, countries, companies and forecasts to 2026 covered in a latest research
Saline laxatives are used to treat constipation or to cleanse the colon in preparation for a colonoscopy. Saline laxative work by absorbing water into the intestine, which softens the stool. These drugs rapidly increase the frequency of complete bowel actions, reduce constipation-associated symptoms and improve disease-related quality of life. Mild saline laxatives such as milk of magnesia and oral magnesium hydroxide have been used to treat constipation during pregnancy.
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Increasing number of constipation incidences coupled with rising geriatric population base worldwide is the major factor driving the saline laxatives market growth. Low fluid and fibre diet intake may also play a major role in onset of constipation. According to the AGA Journal 2011 data, constipation affects 12% to 19% of Americans every year; its prevalence increases with age and it affects women more than men. Constipation causes psychological impairment, social distress, sexual dysfunction, altered interpersonal relationship, and impairment in quality of life. It has a major impact on social and economic burden. As per U.S. FDA, Americans spend more than US$ 700 million annually on over-the-counter laxatives.
Constipation during pregnancy is a common problem. According to the BMC journal 2012 data, the reported prevalence of constipation in pregnant women varies between 11 to 38% and occurs mostly during the third trimester, although symptoms can be present from 12 weeks gestation. However, most obstetricians advise avoiding laxatives during pregnancy and prescribe stool softeners instead due to its potential side effects.
Increasing prevalence of chronic constipation is expected to drive the saline laxatives market growth
Increasing prevalence of constipation coupled with sedentary lifestyle, consumption of low fluid and fiber diet and rising geriatric population are major factors expected to drive the global saline laxative market growth. According to a National Center for Biotechnology Information (NCBI) study 2016, chronic constipation is a common complaint encountered by both gastroenterologists and primary care physicians, with prevalence estimates ranging from 1% to 8% among the North American population. Moreover, constipation occurs more frequently in women, with a female/male ratio ranging from 1.01 to 3.77.
The burden of chronic constipation also affects work productivity, employment, and social activities. According to the Canadian Journal of Gastroenterology and Hepatology 2007 study, among patients suffering from chronic constipation, 30% believe that they were less productive at work or at school, 13% missed work or school days, and nearly 10% were late or had to leave work or school due to their symptoms. Therefore, demand for saline laxatives is significantly boosting with increasing cases of chronic constipation.
Saline Laxatives Market Restraints
However, potential side effects from increased dose of saline laxatives can limit the saline laxatives market growth. Laxative abuse can lead to serious dysfunction of bowel motility such as cathartic colon, intestinal paralysis, lazy or laxative gut, pancreatitis, irritable bowel syndrome, and other problems.
According to the U.S. Food and Drug Administration (FDA) 2014 publication, more than one dose of Over-The-Counter (OTC) sodium phosphate drugs in 24 hours to treat constipation can cause rare but serious harm to the heart and kidneys and can even cause death. OTC sodium phosphate drug products include enemas used rectally and oral solutions taken orally.
Young children, individuals more than 55 years of age, and patients suffering from dehydration, kidney diseases, bowel obstruction or inflammation can be at high risk for potential adverse events when the recommended dose of saline laxative is exceeded.
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Key players operating in the global saline laxatives market include Beutlich Pharmaceuticals LLC, Bayer AG, C.B. Fleet Company, Inc., Salix Pharmaceuticals, Safeway Inc., Supervalu Inc., The Kroger Company, and Walgreen Co.